Lupus erythematosus - Eritematozni Lupus
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Videti je kot rahlo škrlaten eritem.
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References
Prepoznavanje in razvrščanje cutaneous lupus erythematosus (CLE) predstavlja diagnostični izziv, saj ga razlikuje od systemic lupus erythematosus s prizadetostjo kože. Nedavne študije osvetljujejo genetske, okoljske in imunološke dejavnike, na katerih temelji CLE. Indukcija z zdravili se je posebej izkazala kot eden najpomembnejših sprožilcev za CLE. Zdravljenje vključuje lokalno in sistemsko zdravljenje, vključno z obetavnimi biološkimi zdravili, kot je belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 , z dokazano učinkovitostjo v kliničnih preskušanjih.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) pokriva različne težave s kožo, od katerih so nekatere lahko povezane s širšimi zdravstvenimi težavami. Razdeljen je v različne vrste, na primer acute CLE (ACLE) , sub-acute CLE (SCLE) , and chronic CLE (CCLE) . CCLE obsega discoid lupus erythematosus (DLE) , LE profundus (LEP) , chilblain cutaneous lupus, and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus je skupina avtoimunskih bolezni, ki lahko prizadenejo različne dele telesa. Nekatere vrste, kot je systemic lupus erythematosus (SLE) , vplivajo na več organov, medtem ko druge, kot je cutaneous lupus erythematosus (CLE) , vplivajo predvsem na kožo. Različne vrste CLE kategoriziramo na podlagi mešanice kliničnih znakov, pregleda tkiva in krvnih preiskav, vendar je med posamezniki veliko razlik. Težave s kožo se pogosto razvijejo zaradi dejavnikov, kot so izpostavljenost sončni svetlobi, kajenje ali nekatera zdravila.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Vzrok eritematozni lupus (lupus erythematosus) ni jasen. Pri enojajčnih dvojčkih obstaja 24-odstotna verjetnost, da bo prizadet tudi drugi. Tveganje naj bi povečali tudi ženski spolni hormoni, sončna svetloba, kajenje, pomanjkanje vitamina D in nekatere okužbe.
Zdravljenje lahko vključuje nesteroidna protivnetna zdravila, kortikosteroide, imunosupresive, hidroksiklorokin in metotreksat. Čeprav so kortikosteroidi učinkoviti, ima dolgotrajna uporaba stranske učinke.